High-altitude wetlands (HAWs) in the Indian Himalayan Region (IHR) serve as a crucial link between mountain ecology and regional hydrology. This study examines the seasonal fluctuations in surface water dynamics and water quality of the HAWs in Sikkim, an Indian state in the eastern Himalayan area. This study examines seasonal variations in surface water extent in the HAWs from 2016 to 2023 using remote sensing-based indicators, including the normalized difference water index (NDWI), modified normalized difference water index (MNDWI), and normalized difference turbidity index (NDTI). While occasional storms may cause temporary surges in turbidity, elevated summer temperatures and increased evaporation rates result in diminished NDWI and MNDWI readings, signifying reduced water levels, and lower NDTI values indicate improved water clarity. Elevated precipitation during the monsoon season results in heightened water levels, thus leading to a substantial rise in the NDWI and MNDWI. Concurrently, NDTI readings increase, signifying heightened turbidity due to sediment-laden runoff. During the winter season, NDWI and MNDWI values vary; diminished readings indicate enhanced water conditions, whilst unfrozen regions have markedly elevated values, and frozen parts provide reduced ranges. The results illustrate the dynamic nature of these wetlands throughout time and underscore the necessity for continuous monitoring and adaptive management to preserve ecosystem health, ensure sustainable water resource utilization, and mitigate the impacts of climate change in this susceptible high-altitude region.