Emerging convergence between global climate change and biodiversity agendas highlights the need for integrated responses to these grand challenges. However, examples of successful approaches to tackling this ‘twin crisis’ remain limited. This presentation draws on recent efforts in North America’s Yellowstone to Yukon region, which have focused on producing co-benefits for biodiversity conservation and climate change at large spatial scales. This includes efforts to protect and connect core habitat, to demonstrate the carbon storage and sequestration benefits of such efforts, and to steer adaptations towards approaches that attend to interdependencies between people and nature in a changing climate. Through tangible examples, this talk aims to demonstrate productive alignment between large-mountainscape conservation and key objectives of convergent climate change and biodiversity agendas.