Innovative approaches are urgently needed to address the complex challenges posed by climate change, particularly in mountain regions where its impacts are rapid and more pronounced than in urban areas. In this context, the MountResilience project, funded by Horizon Europe, aims to enhance the adaptive capacity of local communities through a multi-level stakeholder engagement process that integrates local knowledge with scientific expertise. The innovative approach developed by MountResilience begins with reconstructing impact chains (ICs) to assess risk and vulnerability through bilateral interviews across the quadruple helix stakeholders. Building on this local knowledge, the project adapts and reinterprets European engagement frameworks, such as the Regional Adaptation Support Tool (RAST) and the TransformAr playbook, to align with local expertise via a decision-making process that validates early-collected information. In this context, Nature-Based Solutions (NBS) are crucial for enhancing the resilience of mountain territories by synergizing ecological sustainability with social resilience: in fact, they improve communities’ abilities to anticipate and respond to climate-induced disturbances while offering multiple benefits. This method also has incorporated the use of a bibliographic collection of solutions to climate change, focused on Nature-Based Solutions (NBS). Originally designed to cover specific areas of interest for MountResilience regional demonstrators, the database has been implemented by collecting articles and projects related to mountain areas: it includes reviews, case studies, engagement methods, innovative ideas, and traditional approaches, and stakeholders can have access to this source of knowledge through a free, user-friendly online tool available on the MountResilience website. This interdisciplinary approach, integrating local stakeholder engagement with scientific research, is fundamental to addressing climate change challenges. In that working flow, the Solution Database can offer ideas and suggestions for local needs, facilitating the understanding of climate change and accelerating decision-making and solution adoption in mountain areas.