Weather and climate in South America is influenced by a large variety of processes, including land-atmosphere and ocean-atmosphere interactions, orographic effects, and land use changes. In addition, human-induced climate change is affecting the region in a wide variety of manners. The contribution of the Working Group I (WGI) to the Sixth Assessment Report (AR6) of the Intergovernmental Panel on Climate Change (IPCC) provides a comprehensive assessment of the scientific evidence published up to 2021, regarding the observed and projected changes in the region in association with climate change. This talk presents an updated synthesis of the main projections of climate change for South America, particularly in the Andes, according to studies published after the IPCC AR6 WGI. It is clear that the amount of published scientific studies for South America has considerably increased during the last few years. The most recent literature confirms many of the projections presented in the IPCC AR6 WGI but expands on projections for different aspects of the regional atmospheric circulation and compound extremes not assessed in the IPCC AR6 WGI. However, despite the increasing amount of peer-reviewed literature during recent years, it is important to highlight that projections of annual and seasonal precipitation in South America still exhibit large spread and uncertainty. Therefore, the necessity of producing high-resolution projections in South America is key, as well as the importance of applying fit-for-purpose analysis focused on the models with physically consistent simulations of regional climate. This hopes to be helpful in the building of the assessment of the physical aspects of climate change in South America to be presented in the next IPCC Assessment Report (AR7).