Nepal, a mountainous country with complex topography, is highly vulnerable to cascading multi-hazards such as earthquakes triggering landslides. These interconnected hazards often amplify disaster impacts, posing significant challenges for risk assessment and preparedness planning. This study focuses on developing a computational framework to assess the cascading effects of multi-hazards in Nepal. Using geospatial data, hazard modelling, and ensemble scenario simulations, we analyze the interactions between primary and secondary hazards triggered by seismic activities. The framework integrates hazard propagation pathways to quantify their combined impact on infrastructure and communities. This research provides actionable insights for policymakers and disaster management agencies to enhance resilience in high-risk mountainous regions like Nepal.