Western science and local knowledge are often rooted in distinct epistemological and ontological frameworks, leading to divergent ideologies and approaches to understanding phenomena, including risks and risk perceptions. This work explores the potential for collaboration between western or natural science and local knowledge to better comprehend flood risks in mountainous regions, using the 2012 Seti River flash flood in central Nepal as a case study. In this study the scientific knowledge—supported by facts, figures, and models—explains the flood as a consequence of increased water levels triggered by changing precipitation patterns, rapid glacier melt, glacial lake outbursts, landslides, and river blockages. On the other hand, local narratives attribute the flood to moral decay, cosmological imbalances, spiritual indeterminacy, greed, and environmental disruptions. The study also examines the failure of a relocation program for flood-affected households, highlighting the disconnect between external interventions and local realities. Findings underscore that while western science and local perspectives differ fundamentally in their explanations of risk, neither approach alone can fully account for the complexity of flood-induced risks. In this work we are mainly focus on the interaction and collaboration between these knowledge systems that can serve as a critical meeting point for achieving a more contextual and holistic understanding of risks. By integrating diverse epistemologies, this study advocates for interdisciplinary approaches to risk assessment and disaster management.